Patients with thyroid dysfunction, with hypothyroidism and hyperthyroidism, may be at a 1.5 times greater risk of developing Parkinson disease, according to the results of a new study presented at the American Academy of Clinical Endocrinology annual meeting AACE 2022.
Citing an interest in building upon previous researching linking thyroid dysfunction and Parkinson disease, Nipith Charoenngam, MD, a postdoctoral research fellow at Boston Medical Center and a team of colleagues (Thanitsara Rittiphairoj, Ben Ponvilawan and Klaorat Prasongdee) from Massachusetts-based institutions designed a systematic review and meta-analysis with the intent of assessing this association in eligible cohort and case-control studies published through 2021.
With this in mind, investigators performed a search of the Medline and EMBASE databases form inception through December 2021, which yielded 3147 particles for potential inclusion in the analysis.
Of note, all 6 case-control studies included patients with hypothyroidism and 5 contained patients with hyperthyroidism.
Upon analysis, results indicated there was an increased likelihood of Parkinson disease was greater among those with hypothyroidism and those with hyperthyroidism.
“Possible explanations include, first, the dysfunction of dopaminergic neurons in the presence of thyroid hormone deficiency.
Also, oxidative stress in the neuron due to thyroid hormone excess could be the explanation for the association between hyperthyroidism and Parkinson Disease,” added Charoenngam.
“Also, shared genetic predisposition and neuroinflammation in autoimmune thyroid disease could be possible explanations as well.”
In any case, the relationship between disorders of the thyroid gland and the risk of developing Parkinson’s disease seems to be confirmed.
Per saperne di più
Thyroid Dysfunction and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis
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