Spleen cells appear in blue; bacteria are stained red.© Ana Hennino, David Bauché, Emilie Plantamura / CIRI.
Epidemiological data suggest a link between changes in gut microbiota composition and the development of skin allergies, like eczema.
Over the last few years, scientists have discovered connections between gut microbiota imbalances and various diseases.
Now, in a study using mice, biologists from the CNRS, INSERM, and Claude Bernard Lyon 1 University—together with colleagues from the Institut Pasteur de Lille and the NIH (USA)—have revealed a surprising relationship between a viral detection system, the composition of the gut microbiota, and the development of skin allergies.
Their findings, published in PNAS (September 24, 2018) suggest potential new therapies.
The number of microorganisms hosted in our digestive tracts is 10 to 100 times greater than that of all the cells that make up our bodies, and the delicately balanced ecosystem they constitute may be modified by our diet and medication.
At the International Center for Infectiology Research (CNRS / INSERM / Claude Bernard Lyon 1 University / ENS de Lyon)—or CIRI—a team led by two researchers from the CNRS focused their attention on mice deprived of the MAVS gene, which plays a key role in the detection of viruses by the immune system.
Flora intestinale
They noted an altered gut microbiota and severe allergic skin reactions in these mice.
To demonstrate a relationship between the two phenomena, the researchers transferred the altered microbiota to normal mice.
The latter in turn developed severe allergic reactions, showing that the transplanted gut bacteria were responsible.
Furthermore, the biologists revealed that such modification of the gut microbiota led to greater intestinal permeability, which allowed certain intestinal bacteria to migrate to the spleen and lymph nodes and increased the severity of allergic skin reactions.
These findings shed light on the unexpected role played by an antiviral protein (MAVS) in the maintenance of gut microbiota equilibrium.
By showing that changes in the gut microbiota exacerbate the allergic response in the skin, this research sets the stage for the development of new therapies.
In the not so distant future, might we treat eczema, or enhance already existing treatments, by acting on the microbiota? This approach is already being investigated for other diseases, like cancer.
See also:
Diet Affects Autoinflammatory Disease Via Gut Microbes (2014-11-10)
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Gut Microbes Linked to Rheumatoid Arthritis (2013-11-26)
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Four gut bacteria decrease asthma risk in infants (2015-10-12)
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Skin sensitivity to food allergens explained (18/10/2011)
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For more information
PNAS
MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype
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CNRS
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MDN
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