High intakes of vitamins B6 and B12 are associated with an increased risk of hip fracture in older women, a cohort study of 75, 864 US postmenopausal women found.

To verify if high intakes of vitamins B6 and B12 from food and supplements were associated with a risk of hip fracture, 75’864 postmenopausal women in the United States were followed up from June 1984 through May 2014.

Information on hip fracture and a wide range of potential confounders was collected at baseline and with biennial follow-up questionnaires.

Extensive dietary information was collected approximately every 4 years with a semiquantitative food frequency questionnaire.

Compared to women who had the lowest intake of both vitamins, women who had the highest daily intake – at least 35 mg of B6 and 20 mcg of B12 – were 47 percent more likely to have hip fractures during the study.

These results add to the evidence suggesting that caution should be used in vitamin supplementation when there is no apparent deficiency.

For more information
Association of High Intakes of Vitamins B6 and B12 From Food and Supplements With Risk of Hip Fracture Among Postmenopausal Women in the Nurses’ Health Study

UiO: University of Oslo


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