Insaccati e carne conservata

Inorganic phosphate, a food additive and preservative used in up to 70 percent of food in the American diet, may be contributing to couch potato behavior.

“We should not consume more than 700 milligrams of inorganic phosphate per day, but about one-third of people consume three to four times that amount,” said Dr. Wanpen Vongpatanasin, Professor of Internal Medicine and Director of the Hypertension Fellowship Program at UT Southwestern Medical Center.

“Like any nutritional ingredient, too little phosphate is harmful, but too much is also harmful.”

Phosphates occur naturally in many foods, including dairy products, meat, fish, and baking powder, but it is the consumption of fast foods, processed foods, and bottled drinks that can push phosphate levels up, said Dr. Wanpen Vongpatanasin.

For example, a block of Parmesan cheese contains phosphates, but when Parmesan is sold in a grated or shredded form, additional phosphates may be added to keep it from sticking.

When examining food labels, look for anything that contains “phos-,” such as calcium phosphate, disodium phosphate, or monopotassium phosphate.

Adding to the problem is the lack of information on inorganic phosphate.

Looking at food labels won’t help, Dr. Vongpatanasin said.
“Currently there are no mandates or regulations for the food industry to label how much inorganic phosphate is in the food chain.”

The new study describing the adverse effects of excess consumption of phosphate is published in the journal Circulation.

Phosphate is plentiful in fruits and vegetables in its organic form, which does not cause problems because it is not absorbed.

However, the body readily absorbs inorganic phosphate, and most people are consuming far too much of it.

For example, cola drinks, processed meats, and prepared frozen foods typically contain this additive.

When the researchers studied mice that were fed a high-phosphate diet, they found measureable changes in their ability to exercise.

“We measured their oxygen uptake during exercise and found that their capacity for movement was much lower.

The mice were unable to generate enough fatty acids to feed their muscles,” Dr. Vongpatanasin said.

The researchers also looked for gene changes and found that many genes involved in skeletal muscle metabolism had changed levels after 12 weeks of the high phosphate diet.

In addition, the study analyzed data from participants in the Dallas Heart Study who wore physical activity monitors for seven days.

The multiethnic participants, ages 18 to 65, had no kidney or heart problems and were not on medications.

Researchers examined blood test results in this group and verified that the response to phosphate in humans was similar to that in mice.

Higher phosphate levels were linked to reduced time spent in moderate to vigorous exercise, while sedentary time increased as phosphate levels climbed.

Since inorganic phosphate is widely used in the food supply, the UT Southwestern research team concluded that more studies are needed to further define the broader health impact of this substance.

The Food and Drug Administration and the U.S. Department of Agriculture establish requirements for food labels in the U.S.

The Dallas Heart Study was initiated in 2000 with the primary goal of improving the diagnosis, prevention, and treatment of heart disease.

It is the only single-center heart study of its size and multiethnic composition.

Dr. Vongpatanasin holds the Norman and Audrey Kaplan Chair in Hypertension and the Fredric L. Coe Professorship in Nephrolithiasis Research in Mineral Metabolism.

Other UT Southwestern researchers who contributed to this work include: Dr. Gary Iwamoto, Professor of Cell Biology; Dr. Jere Mitchell, Professor of Internal Medicine and Physiology; Dr. Scott A. Smith, Assistant Dean for Research, Professor and Acting Chair of Health Care Sciences; Dr. Han Kyul Kim, postdoctoral fellow in Cardiology; Dr. Luke I. Szweda, Professor of Internal Medicine; Dr. Rhonda Bassel-Duby, Professor of Molecular Biology; Dr. Carlos M. Castorena, Instructor of Internal Medicine; Dr. James Richardson, Professor Emeritus of Pathology; John M. Shelton, Operations Director of the Histo Pathology Core; Colby Ayers, Internal Medicine Faculty Associate; Dr. Jarett D. Berry, Associate Professor of Internal Medicine and Clinical Sciences; Dr. Venkat S. Malladi, Assistant Professor of Pathology; Dr. Ming Chang Hu, Associate Professor Internal Medicine and Pediatrics; Dr. Orson W. Moe, Professor of Internal Medicine and Physiology; and Dr. Philipp E. Scherer, Professor of Internal Medicine and Cell Biology.

Dr. Mitchell holds the S. Roger and Carolyn P. Horchow Chair in Cardiac Research, in Honor of Jere H. Mitchell, M.D. Dr. Berry is a Dedman Family Scholar in Clinical Care. Dr. Moe holds The Charles Pak Distinguished Chair in Mineral Metabolism and the Donald W. Seldin Professorship in Clinical Investigation. Dr. Scherer holds the Gifford O. Touchstone, Jr. and Randolph G. Touchstone Distinguished Chair in Diabetes Research.

See also
Flame retardants linked to female infertility (2017-09-04)
…Women with high concentrations of organophosphate flame retardants (PFRs) in their urine may have a hard time getting pregnant and carrying a baby to term…

FDA for consumers: Use Certain Laxatives with Caution (2014-01-30)
… there have been dozens of reports of serious side effects, including 13 deaths, associated with the use of sodium phosphate laxatives…

Are sigarettes radioactive?(20/08/2012)
…For example, phosphate fertilizers, favored by the tobacco industry, contain radium and its decay products (including lead-210 and polonium-210)…

Treating chronic kidney disease using clay minerals (2014-01-03)
…When suffering from renal failure, the body is unable to filter out phosphates in sufficient quantities, and the resulting excess is then absorbed into the blood…

For more information
High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice

Phosphates in processed foods may hike blood pressure

UT Southwestern
Medical Center


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