ARecent studies have shed light on the mechanisms by
which stress and glucocorticoids affect glutamate
transmission, including effects on glutamate
release, glutamate receptors and glutamate clearance
and metabolism..
This new understanding provides insights into normal
brain functioning, as well as the pathophysiology
and potential new treatments of stress-related
neuropsychiatric disorders.
Mounting evidence suggests that acute and chronic
stress, especially the stress-induced release of
glucocorticoids, induces changes in glutamate
neurotransmission in the prefrontal cortex and the
hippocampus, thereby influencing some aspects of
cognitive processing.
In addition, dysfunction of glutamatergic
neurotransmission is increasingly considered to be a
core feature of stress-related mental illnesses.
For more information
Nature Reviews Neuroscience
The stressed synapse: the impact of stress and
glucocorticoids on glutamate transmission
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