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your best life. Online since 1998Muscular dystrophies are severe genetic diseases for which no efficacious therapies exist.
Experimental clinical treatments include intra-arterial administration of vessel-associated stem cells, called mesoangioblasts (MABs).
However, one of the limitations of this approach is the relatively low number of cells that engraft the diseased tissue, due, at least in part, to the sub-optimal efficiency of extravasation, whose mechanisms for MAB are unknown. Leukocytes emigrate into the inflamed tissues by crossing endothelial cell-to-cell junctions and junctional proteins direct and control leukocyte diapedesis. Here, researchers identify the endothelial junctional protein JAM-A as a key regulator of MAB extravasation. Researchers show that JAM-A gene inactivation and JAM-A blocking antibodies strongly enhance MAB engraftment in dystrophic muscle. In the absence of JAM-A, the exchange factors EPAC-1 and 2 are down-regulated, which prevents the activation of the small GTPase Rap-1. As a consequence, junction tightening is reduced, allowing MAB diapedesis. Notably, pharmacological inhibition of Rap-1 increases MAB engraftment in dystrophic muscle, which results into a significant improvement of muscle function offering a novel strategy for stem cell-based therapies.
For more information
Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles
MDN
del Dott. Turetta
Quali sono i problemi o le disfunzioni che possono giovarsi di un intervento omeopatico d'urgenza e, di conseguenza, come dovrebbe essere un ideale armadietto medicinale omeopatico casalingo.Copyright © 1998/2018 www.mybestlife.com tutti i diritti sono riservati eccetto quelli già di altri proprietari.
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