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The natural polyamine spermidine could extend Cardioprotection and lifespan (2016-11-15)

Aging is associated with an increased risk of cardiovascular disease and death and a new study shows that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice.

Spermidine is a naturally occurring chemical that is produced within the body. It is also found in a large number of foods, including cheese, mushrooms, soy and whole grains.
Early tests in mice show that spermidine restores the immune systemís inbuilt memory enabling it to mount a more powerful protective response following vaccination (Link...).

Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation.

Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure.

In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease.

See also
New drug could make flu vaccines more effective in the elderly (2014-11-28)

Epigenomic changes are key to innate immunological memory (2015-09-23)

For more information
nature medicine
Cardioprotection and lifespan extension by the natural polyamine spermidine