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Peyronie: hyaluronic acid injections may benefit men (2016-05-04)

A pilot study investigating intralesional injections of hyaluronic acid for treatment of Peyronie’s disease has shown encouraging preliminary results.

Peyronie's disease (PD) is an acquired, localized fibrotic disorder characterized by the deposition of collagen and fibrin in the form of plaque on the tunica albuginea of the penis, just under the skin.
These plaques cause the penis to lose some of its flexibility.
The penis starts to curve, making intercourse difficult or impossible.
Its pathophysiology is unknown and frequently results in penile deformity, penile pain, and erectile dysfunction leading to a significant negative impact on patient quality of life, with associated rates of significant depression up to 48%. Recent prevalence estimates vary from 3.2% to 8.9%.

Scientists are not certain what causes Peyronie’s disease, but many believe it stems from a wound that is not healing properly.

This prospective, multicenter, pilot study assessing the efficacy of hyaluronic acid as intralesional treatment for patients with PD showed encouraging preliminary results for improvement of plaque size, penile curvature, and overall sexual satisfaction.

This therapeutic approach seems to be preferably indicated in the early (active) phase of the disease. Intralesional treatment with hyaluronic acid is easy to perform and well tolerated, with null risk of local or systemic side effects.

For more information
Intralesional Injection of Hyaluronic Acid in Patients Affected With Peyronie's Disease: Preliminary Results From a Prospective, Multicenter, Pilot Study
Alessandro Zucchi, MD, Elisabetta Costantini, MD, Tommaso Cai, MD, Giorgio Cavallini, MD, Giovanni Liguori, MD, Vincenzo Favilla, MD, Gaetano De Grande, MD, Giuseppe D'Achille, MD, Mauro Silvani, MD, Giorgio Franco, MD, Alessandro Palmieri, MD, Paolo Verze, MD, PhD, Vincenzo Mirone, MD.