Illustration of the ultrastructure of the Covid-19 virus

Covid-19: two drugs against Sars-CoV-2 were designed and synthesized by the Wenhao Dai team, of the Chinese Academy of Sciences.

Sars-CoV-2 is the etiological agent responsible for the global COVID-19 outbreak.

The main protease (Mpro) of Sars-CoV-2 is a key enzyme that plays a pivotal role in mediating viral replication and transcription.

Scientists designed and synthesized two lead compounds (11a and 11b) targeting Mpro.

Both exhibited excellent inhibitory activity and potent anti-Sars-CoV-2 infection activity.

Both compounds showed good PK properties in vivo, and 11a also exhibited low toxicity, suggesting that these compounds are promising drug candidates.

See also:

Trial drug can significantly block early stages of COVID-19 in engineered human tissues (2020-04-10)

COVID-19, antimalarial drugs, malaria and blood type (2020-04-04)

Hydroxychloroquine and azithromycin as a treatment of COVID-19 (2020-03-18)

For more information
The link to the original article:
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease


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