Washington State University researchers have created more than a dozen candidate drugs with the potential to curb smokers’ desire for nicotine by slowing how it is broken down in the body.
The researchers hope the substances can help people reduce their consumption of tobacco, if not quit altogether.
The discovery, published in the Journal of Medicinal Chemistry, targets a liver enzyme, called CYP2A6, which metabolizes nicotine.
There are approximately 600 ingredients in cigarettes.
When burned, they create more than 7,000 chemicals.
At least 69 of these chemicals are known to cause cancer, and many are poisonous.
Many of these chemicals also are found in consumer products, but these products have warning labels.
While the public is warned about the danger of the poisons in these products, there is no such warning for the toxins in tobacco smoke:
Acetone – found in nail polish remover
Acetic Acid – an ingredient in hair dye
Ammonia – a common household cleaner
Arsenic – a poison, used in wood preservatives and in rat poison
Benzene – an industrial solvent, refined from crude oil
Beryllium – used in nuclear reactors
Butane – used in lighter fluid
Cadmium – used in batteries
Chromium – used to manufacture dye, paints and alloys
Carbon Monoxide – released in car exhaust fumes
Ethylene oxide – a disinfectant used to sterilise hospital equipment
Formaldehyde – embalming fluid used in mortuaries and paint manufacturing
Hexamine – found in barbecue lighter fluid
Lead – used in batteries
Naphthalene – an ingredient in mothballs
Methanol – a main component in rocket fuel
Nicotine – used as insecticide
1,3-Butadiene – used in rubber manufacturing
Nickel – used to protect metals from corrosion
Ortho-Toluidine – used in the production of weedkillers
Polycyclic aromatic hydrocarbons – a group of dangerous DNA-damaging chemicals, including benzo(a)pyrene
Polonium-210 – a highly radioactive element
Tar – material for paving roads
Toluene – used to manufacture paint
Vinyl chloride – used to produce plastic and vinyl products
4-aminobiphenyl and 2-naphthyl-amine – used in dye manufacturing until it was banned in the EU
And then there are tobacco-specific nitrosamines – a group of cancer-causing chemicals only found in tobacco.
If you want to stop smoking and you really decided to stop, you will stop.
For more information
Journal of Medicinal Chemistry
Identification of the 4-Position of 3-Alkynyl and 3-Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P-450 2A6 Inhibition
Washington State University
American Lung Association
What’s In a Cigarette?
American Lung Association
E-cigarettes and Lung Health
Cancer Research UK
What’s in a cigarette?
A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction
EUROPA > DG Health and Consumer Protection > Public Health
American Journal of Public Health®
Pharmacological and Chemical Effects of Cigarette Additives
In 1994 Brown and Williamson (one of largest tobacco manufacturers in the USA) published a list of all the additives used in their cigarettes which includes information on the sources of the additives and their side-effects
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