Attività fisica

Biological and chronological age often do not coincide and several researchers have sought the most reliable means to predict the length of life.
Here are the last two research published on the subject.

Cleveland Clinic researchers have developed a tool to calculate a person’s physiological age based on their exercise performance during a stress test and found this is a better predictor of how long they’ll live compared to their actual age.

A newly discovered ribosomal DNA (rDNA) clock can be used to accurately determine an individual’s chronological and biological age, according to research led by Harvard T.H. Chan School of Public Health.


Cleveland Clinic

Researchers studied 126,356 patients who were referred for an exercise treadmill testing (electrocardiography, echocardiography or myocardial perfusion imaging) at Cleveland Clinic between Jan. 1, 1991, and Feb. 27, 2015, to evaluate whether a patient’s estimated age based on their exercise performance is a better predictor of mortality when compared to chronological age.

The average age of study participants was 53.5 years old and 59 percent were male.

The study found that the estimated age based on exercise performance was better in predicating survival than the patients’ actual age.

This held true for both male and female cohorts, when considered separately.

Among those included, 55% of males and 57% of females between the ages of 50 and 60 years had their estimated age younger than their chronologic age.

The formula to estimate physiological age was developed based on exercise variables that were collected at the time of the patient’s stress test.

Estimated age was computed based on exercise capacity (number of peak estimated metabolic equivalents of task), chronotropic reserve index and heart rate recovery, taking into account patient’s gender and medications that affect heart rate.

Harvard T.H. Chan School of Public Health

The ribosomal clock is a novel biomarker of aging based on the rDNA, a segment of the genome that has previously been mechanistically linked to aging.

The ribosomal clock has potentially wide applications, including measuring how exposures to certain pollutants or dietary interventions accelerate or slow aging in a diversity of species, including mice and humans.

Age is the major risk factor for a plethora of diseases, including neurological diseases, cardiovascular diseases, and cancer.

There are two types of age: chronological age, or the number of years a person or animal has lived, and biological age, which accounts for various lifestyle factors that can shorten or extend lifespan, including diet, exercise, and environmental exposures.

Overall, biological age has been shown to be a better predictor of all-cause mortality and disease onset than chronological age.

For this new study, the researchers looked at the rDNA, the most active segment of the genome and one which has also been mechanistically linked to aging in a number of previous studies.

Lemos and lead author Meng Wang, a research fellow in the Department of Environmental Health, hypothesized that the rDNA is a “smoking gun” in the genomic control of aging and might harbor a previously unrecognized clock.

To explore this concept, they examined epigenetic chemical alterations (also known as DNA methylation) in CpG sites, where a cytosine nucleotide is followed by a guanine nucleotide.

The study homed in on the rDNA, a small (13 kilobases) but essential and highly active segment of the genome, as a novel marker of age.

Analysis of genome-wide data sets from mice, dogs, and humans indicated that the researchers’ hypothesis had merit: numerous CpGs in the rDNA exhibited signs of increased methylation—a result of aging.

To further test the clock, they studied data from 14-week-old mice that responded to calorie restriction, a known intervention that promotes longevity.

The mice that were placed on a calorie-restricted regimen showed significant reductions in rDNA methylation at CpG sites compared with mice that did not have their caloric intake restricted.

Moreover, calorie-restricted mice showed rDNA age that was younger than their chronological age.

The researchers were surprised that assessing methylation in a small segment of the mammalian genome yielded clocks as accurate as clocks built from hundreds of thousands of sites along the genome.

They noted that their novel approach could prove faster and more cost effective at determining biological and chronological age than current methods of surveying the dispersed sites in the genome.

The findings underscore the fundamental role of rDNA in aging and highlight its potential to serve as a widely applicable predictor of individual age that can be calibrated for all mammalian species.

Importantly, the clocks respond to interventions, which could allow scientists to study how biological age responds to environmental exposures and lifestyle choices.

Being able to ascertain an accurate biological age can give a person an indication of how much better or worse he or she is doing relative to the general population and could potentially help monitor whether someone is at heightened risk of death or a certain disease.

For more information
Genome Research
Ribosomal DNA harbors an evolutionarily conserved clock of biological aging

Harvard T.H. Chan School of Public Health

European Journal of Preventive Cardiology
Estimated age based on exercise stress testing performance outperforms chronological age in predicting mortality

Cleveland Clinic


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