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Extra virgin olive oil (EVOO) consumption has been
associated with reduced cardiovascular risk but
molecular mechanisms underlying its beneficial
effects are not fully understood. Researchers aimed
to identify genes and miRNAs expression changes
mediated by acute high- and low-polyphenols EVOO
intake.
Pre and post-challenge
gene and miRNAs expression analysis was performed on
the peripheral blood mononuclear cells (PBMCs) of 12
healthy subjects and 12 patients with metabolic
syndrome (MS) by using microarray and RT-qPCR.
In healthy subjects,
acute intake of EVOO rich in polyphenols was able to
ameliorate glycaemia and insulin sensitivity, and to
modulate the transcription of genes and miRNAs
involved in metabolism, inflammation and cancer,
switching PBMCs to a less deleterious inflammatory
phenotype; weaker effects were observed in patients
with MS as well as in healthy subjects following
low-polyphenol EVOO challenge.
Concluding, the new
study shows that acute high-polyphenols EVOO intake
is able to modify the transcriptome of PBMCs through
the modulation of different pathways associated with
the pathophysiology of cardio-metabolic disease and
cancer.
These beneficial effects are maximized in healthy
subjects and by the use of EVOO cultivars rich in
polyphenols.
Nutrigenomic changes
induced by EVOO thus legitimate the well-known
beneficial effects of EVOO in promoting human health
and, potentially, preventing the onset of
cardiovascular disease and cancer.
For more information
Genes and miRNA expression signatures in peripheral
blood mononuclear cells in healthy subjects and
patients with metabolic syndrome after acute intake
of extra virgin olive oilOriginal Research Article
Simona D'Amore, Michele Vacca, Marica Cariello,
Giusi Graziano, Andria D'Orazio, Roberto Salvia,
Rosa Cinzia Sasso, Carlo Sabbà, Giuseppe Palasciano,
Antonio Moschetta
Biochimica et Biophysica Acta (BBA) - Molecular and
Cell Biology of Lipids
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