Aspirin, nonsteroidal antiinflammatory drugs (NSAID),
and acetaminophen are commonly used. Frequent use of
analgesics has been associated with a higher risk of
However, the association between duration of
analgesic use and the risk of hearing loss is
Researchers investigated the relationship between
duration of analgesic use and self-reported hearing
loss among 55,850 women in the Nurses’ Health Study.
Cox proportional hazards regression was used to
adjust for potential confounders.
During 873,376 person-years of follow-up
(1990–2012), longer durations of NSAID use (for >6
years of use compared with <1 year,
multivariable-adjusted relative risk = 1.10, 95%
confidence interval: 1.06, 1.15; P for trend <
0.001) and acetaminophen use (for >6 years of use
compared with <1 year, multivariable-adjusted
relative risk = 1.09, 95% confidence interval: 1.04,
1.14; P for trend < 0.001) were associated with
higher risks of hearing loss.
Duration of aspirin use was not associated with
In this cohort of women, longer durations of NSAID
and acetaminophen use were associated with slightly
higher risks of hearing loss, but duration of
aspirin use was not. Considering the high prevalence
of analgesic use, this may be an important
modifiable contributor to hearing loss.
Popular pain-relieving medicines linked to hearing
loss in women (12/10/2012)
For more information
American Journal of Epidemiology
Duration of Analgesic Use and Risk of Hearing Loss