The purpose of this investigation was to understand
the metabolic adaptations to a short-term (5 days),
isocaloric, high-fat diet (HFD) in healthy, young
males. Two studies were undertaken with 12 subjects.
Study 1 investigated the effect of the HFD on
skeletal muscle substrate metabolism and insulin
sensitivity.
Study 2 assessed the metabolic and transcriptional
responses in skeletal muscle to the transition from
a fasted to fed state using a high-fat meal
challenge before and after 5 days of the HFD.
Study 1 showed no effect of a HFD on skeletal muscle
metabolism or insulin sensitivity in fasting
samples.
Study 2 showed that a HFD elicits significant
increases in fasting serum endotoxin and disrupts
the normal postprandial excursions of serum
endotoxin, as well as metabolic and transcriptional
responses in skeletal muscle.
These effects after 5 days of the HFD were
accompanied by an altered fasting and postprandial
response in the ratio of phosphorylated - to total -
p38 protein. These changes all occurred in the
absence of alterations in insulin sensitivity.
The study provide evidence for early biological
adaptations to high-fat feeding that proceed and
possibly lead to insulin resistance.
For more in formation
Obesity (Silver Spring). 2015 Apr;23(4):720-4. doi:
10.1002/oby.21031.
Early skeletal muscle adaptations to short-term
high-fat diet in humans before changes in insulin
sensitivity
http://www.ncbi.nlm.nih.gov/pubmed/25820254.
MDN |