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Thyroid hormone plays an imperative role in the
regulation of cellular metabolism, proliferation and
differentiation. There are two basic forms of
thyroid hormone: T4 and T3. The two forms of thyroid
hormone are produced and secreted by the follicular
cells of the thyroid gland.
The concept that thyroid hormone may act as a growth
factor for the breast cancer has been reported by
various scientists. The thyroid hormone receptors
and steroids belong to the same family with similar
molecular structure, but having different
transcriptional functions which define their genomic
actions.
Ovarian cancer is also a hormone-dependent neoplasm
like breast cancer.
A new study was designed to investigate variations
in the levels of thyroid hormones (T3, T4) in breast
and ovarian cancers patients.
A total 120 subjects were recruited (without thyroid
history) divided into three groups; A, B and C.
Group A as control with healthy individuals. While
group B and group C were consisting of breast cancer
and ovarian cancer patient respectively.
Blood samples (5 ml) were taken and analyzed to
estimate the levels of serum T3 (tri-iodothyronine)
and T4 (thyroxin) hormones. Statistically
significant difference was obtained among all
groups.
A significant increase in T3 and T4 levels was
observed among breast cancer patients as compared to
healthy controls. While for ovarian cancer patients
conflicting results were found for T3 and T4 levels
in the serum i.e. insignificant difference was found
in T3 and T4 as compared to control.
The results showed that in the breast cancer and
ovarian cancer patients the thyroid hormone (T3 and
T4) level has been altered from the normal ranges as
compared to the normal healthy individuals.
For more information
Comparative Study of Alterations in
Tri-iodothyronine (T3) and Thyroxine (T4) Hormone
Levels in Breast and Ovarian Cancer
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320730/.
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